Bactericidal/permeability-increasing protein prevents mucosal damage in an experimental rat model of chronic otitis media with effusion.

نویسندگان

  • M J Nell
  • H K Koerten
  • J J Grote
چکیده

In this study, the efficacy of bactericidal/permeability-increasing protein (BPI) was assessed in a rat model of chronic otitis media with effusion. BPI injection prevented disturbance of the mucociliary clearance system of the middle ear. Hence, it is postulated that BPI can be a new therapy for chronic otitis media with effusion.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

BPIFA1 Gene Expression in the Human Middle Ear Mucosa.

OBJECTIVE The bactericidal/permeability-increasing, fold-containing family member A1 (BPIFA1) gene codes a secretory protein (BPIFA1), which is present in the respiratory tract mucosa, and is part of the innate immune system. This study aimed to prove that BPIFA1 gene expression exists in the human middle ear mucosa. MATERIALS AND METHODS In total, 32 patients participated in the study betwee...

متن کامل

Study of Correlation of Pre-Operative Findings with Intra-Operative Ossicular Status in Patients with Chronic Otitis Media

Introduction: Chronic otitis media (COM) has been broadly classified into mucosal and squamous subtypes. COM types are associated with erosion of the ossicular chain. The aim of the present study was to correlate the type of COM, the site of perforation/retraction, and the type of disease pathology with the pattern and degree of ossicular chain necrosis.   Materials and Methods: A prospecti...

متن کامل

The role of vascular endothelial growth factor and vascular stability in diseases of the ear.

OBJECTIVES/HYPOTHESIS Vascular endothelial growth factor (VEGF) is a critical mediator of vascular permeability and angiogenesis and likely plays an important role in cochlear function and hearing. This review highlights the role of VEGF in hearing loss associated with vestibular schwannomas, otitis media with effusion, and sensorineural hearing loss. STUDY DESIGN PubMed literature review. ...

متن کامل

Montelukast is as effective as penicillin in treatment of acute otitis media: An experimental rat study

BACKGROUND Leukotrienes are the major factors in the formation of edema and mucus, as well as development of tuba Eustachii dysfunction in acute otitis media. We developed an experimental acute suppurative otitis media model and compared the responses of rats to penicillin and combinations of leukotriene antagonist with respect to histopathological observations conducted in early and late phase...

متن کامل

Comparison of Adenoidectomy and Myringotomy with and without Tube Placement in the Short Term Hearing Status of Children with Otitis Media with Effusion: A Preliminary Report

Dear Editor, I read with enthusiasm the article entitled "Comparison of Adenoidectomy and Myringotomy with and without Tube Placement in the Short Term Hearing Status of Children with Otitis Media with Effusion" by Drs. Shishegar and Hoghoghi, which was published in IJMS 2007; 32:168-171. I think there are grave misconceptions and doubtful materials in the article. I also disagree with some of ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Infection and immunity

دوره 68 5  شماره 

صفحات  -

تاریخ انتشار 2000